Introduction to Genomics PDF

Arthur Mallay Lesk ist ein Proteinforscher und Professor für Biochemie und Molekularbiologie an der Pennsylvania State University in University Park. Lesk erhielt 1961 einen Bachelor-Abschluss, magna cum laude, von der Harvard University. Er promovierte 1966 an der Princeton University. Außerdem erhielt er 1999 einen Master-Abschluss von der University of Cambridge im Vereinigten Königreich. Lesk hat bedeutende Beiträge geleistet zum Studium der Proteinevolution. Er und Cyrus Chothia, die am Labor für Molekularbiologie des Medical Research Council (UK) in Cambridge, Großbritannien, arbeiten, entdeckten die Beziehung zwischen Änderungen in der Aminosäuresequenz und Änderungen in der Proteinstruktur, indem sie den Evolutionsmechanismus in Proteinfamilien analysierten Entdeckung hat die quantitative Grundlage für die erfolgreichste und am weitesten verbreitete Methode zur Strukturvorhersage, bekannt als Homologiemodellierung, geliefert.

Introduction to Genomics pdf von Arthur Mallay Lesk

Our genome is the blueprint to our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism. But it is more than a static information store: our genome is a dynamic, tightly-regulated collection of genes, which switch on and off in many combinations to give the variety of cells from which our bodies are formed. But how do we identify the genes that make up our genome? How do we determine their function? And how do different genes form the regulatory networks that direct the process of life?
Introduction to Genomics is a fascinating insight into what can be revealed from the study of genomics: how organisms differ or match; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genomics means in terms of our future health and wellbeing.
Covering the lastest techniques that enable us to study the genome in ever-increasing detail, the book explores what the genome tells us about life at the level of the molecule, the cell, and the organism. Learning features throughout make this book the ideal teaching and learning tool: extensive end of chapter exercises and problems help the student to fully grasp the concepts being presented, while end of cahpter WebLems (web-based problems) and lab assignments give the student the opportunity to engage with the subject in a hands-on manner.