Introduction to Protein Science: Architecture, Function, and Genomics

Introduction to Protein Science: Architecture, Function, and Genomics PDF

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Arthur Mallay Lesk ist ein Proteinforscher und Professor für Biochemie und Molekularbiologie an der Pennsylvania State University in University Park. Lesk erhielt 1961 einen Bachelor-Abschluss, magna cum laude, von der Harvard University. Er promovierte 1966 an der Princeton University. Außerdem erhielt er 1999 einen Master-Abschluss von der University of Cambridge im Vereinigten Königreich. Lesk hat bedeutende Beiträge geleistet zum Studium der Proteinevolution. Er und Cyrus Chothia, die am Labor für Molekularbiologie des Medical Research Council (UK) in Cambridge, Großbritannien, arbeiten, entdeckten die Beziehung zwischen Änderungen in der Aminosäuresequenz und Änderungen in der Proteinstruktur, indem sie den Evolutionsmechanismus in Proteinfamilien analysierten Entdeckung hat die quantitative Grundlage für die erfolgreichste und am weitesten verbreitete Methode zur Strukturvorhersage, bekannt als Homologiemodellierung, geliefert.

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Introduction to Protein Science: Architecture, Function, and Genomics pdf von Arthur Mallay Lesk

Proteins are essential to life, having a vital role in all living organisms. They are the ultimate micro machines: some are building blocks, joining with other substances to make the cells from which we are all formed. Some are catalysts, speeding up essential biochemical reactions to keep our cells alive. Yet others help cells to communicate, to move, and to build up the complex mix of tissues that make up our bodies. Introduction to Protein Science provides a broad ranging introduction to the contemporary study of proteins suitable for students on biosciences degrees internationally. Starting by describing the structure of proteins and how these structures can be studied, the book goes on to illustrate the wide range of functions that proteins have, showing how the shape of a protein is intimately linked to the function that it has. The book then describes how new experimental and computational techniques are helping us to predict a protein s structure and function, and how this is paving the way for us to design new proteins with specific characteristics, with exciting implications in areas such as drug design. Written by Arthur Lesk, the author of the highly successful Introduction to Bioinformatics, this book offers the same clear, student friendly approach to an equally important area of bioscience. Recent advances in genomics and proteomics have paved the way for an explosion of interest in protein structure and function. This book captures the current state of excitement in a way that all biosciences students will find appealing. Online Resource Centre: - Downloadable figures - A Web link library - Animated illustrations (pictures of complicated structures are much more effective if presented as animations; this will take the form of a computer-readable supplement to the book).

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