Introduction to Genomics pdf

Arthur Mallay Lesk, is a protein science researcher, who is a professor of biochemistry and molecular biology at the Pennsylvania State University in University Park. Lesk received a bachelor's degree, magna cum laude, from Harvard University in 1961. He received his doctoral degree from Princeton University in 1966. He also received a master's degree from the University of Cambridge in the United Kingdom in 1999. Lesk has made significant contributions to the study of protein evolution. He and Cyrus Chothia, working at the Medical Research Council (UK) Laboratory of Molecular Biology in Cambridge, United Kingdom, discovered the relationship between changes in amino-acid sequence and changes in protein structure by analyzing the mechanism of evolution in protein families.This discovery has provided the quantitative basis for the most successful and widely used method of structure prediction, known as homology modelling.

Introduction to Genomics pdf by Arthur Mallay Lesk

Our genome is the blueprint to our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism. But it is more than a static information store: our genome is a dynamic, tightly-regulated collection of genes, which switch on and off in many combinations to give the variety of cells from which our bodies are formed. But how do we identify the genes that make up our genome? How do we determine their function? And how do different genes form the regulatory networks that direct the process of life?
Introduction to Genomics is a fascinating insight into what can be revealed from the study of genomics: how organisms differ or match; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genomics means in terms of our future health and wellbeing.
Covering the lastest techniques that enable us to study the genome in ever-increasing detail, the book explores what the genome tells us about life at the level of the molecule, the cell, and the organism. Learning features throughout make this book the ideal teaching and learning tool: extensive end of chapter exercises and problems help the student to fully grasp the concepts being presented, while end of cahpter WebLems (web-based problems) and lab assignments give the student the opportunity to engage with the subject in a hands-on manner.