Tissue and Organ Regeneration: Advances in Micro- and Nanotechnology pdf

Professor Lijie Grace Zhang's Bioengineering Laboratory for Nanomedicine and Tissue Engineering applies a range of interdisciplinary technologies and approaches in 3D/4D bioprinting, nanotechnology, tissue engineering, and drug delivery for various biomedical applications. The main ongoing research projects include: developing advanced 3D/4D bioprinting techniques and designing biologically inspired nanostructured scaffolds for complex cardiovascular, neural and musculoskeletal tissue regenerations; investigation of the influence of nano and chemical environments in directing stem cell differentiations for regenerative medicine; developing sustained drug formulations for long term and controlled drug release at disease or cancer sites; developing a novel 3D tunable tissue model for cancer metastasis study; and 4D printing soft biorobotics for biomedical applications.

Tissue and Organ Regeneration: Advances in Micro- and Nanotechnology pdf by Lijie Grace Zhang

Tissue engineering aims to develop biological substitutes that restore, maintain, or improve damaged tissue and organ functionality. To date, numerous stem cells and biomaterials have been explored for a variety of tissue and organ regeneration. The challenge for existing stem cell–based techniques is that current therapies lack controlled environments that are crucial for regulating stem cell engraftment and differentiation in vivo, because stem cells are rather sensitive to even minute changes in their environment. Micro- and nanotechnology hold great potential to fabricate biomimetic spatiotemporally controlled scaffolds as well as control stem cell behavior and fate by micro- and nanoscale cues. This book presents the latest micro- and nanotechnologies used to manipulate stem cell behaviors, which is a critical area for regenerative medicine. Moreover, it covers and details cutting-edge research in nano- and microfabrication techniques and biomaterials for the regeneration of various tissues and organs, such as bone, cartilage, craniofacial, osteochondral, muscle, bladder, cardiac, and vascular tissues.