Introduction to Protein Science: Architecture, Function, and Genomics pdf

Arthur Mallay Lesk, es un investigador de ciencia de proteínas, profesor de bioquímica y biología molecular en la Universidad Estatal de Pensilvania en University Park. Lesk recibió una licenciatura, magna cum laude, de la Universidad de Harvard en 1961. Recibió su doctorado de la Universidad de Princeton en 1966. También recibió una maestría de la Universidad de Cambridge en el Reino Unido en 1999. Lesk ha hecho contribuciones significativas al estudio de la evolución de las proteínas. Él y Cyrus Chothia, trabajando en el Laboratorio de Biología Molecular del Consejo de Investigación Médica (UK) en Cambridge, Reino Unido, descubrieron la relación entre los cambios en la secuencia de aminoácidos y los cambios en la estructura de la proteína al analizar el mecanismo de evolución en las familias de proteínas. El descubrimiento ha proporcionado la base cuantitativa para el método de predicción de estructuras más exitoso y ampliamente utilizado, conocido como modelado de homología.

Introduction to Protein Science: Architecture, Function, and Genomics pdf por Arthur Mallay Lesk

Proteins are essential to life, having a vital role in all living organisms. They are the ultimate micro machines: some are building blocks, joining with other substances to make the cells from which we are all formed. Some are catalysts, speeding up essential biochemical reactions to keep our cells alive. Yet others help cells to communicate, to move, and to build up the complex mix of tissues that make up our bodies. Introduction to Protein Science provides a broad ranging introduction to the contemporary study of proteins suitable for students on biosciences degrees internationally. Starting by describing the structure of proteins and how these structures can be studied, the book goes on to illustrate the wide range of functions that proteins have, showing how the shape of a protein is intimately linked to the function that it has. The book then describes how new experimental and computational techniques are helping us to predict a protein s structure and function, and how this is paving the way for us to design new proteins with specific characteristics, with exciting implications in areas such as drug design. Written by Arthur Lesk, the author of the highly successful Introduction to Bioinformatics, this book offers the same clear, student friendly approach to an equally important area of bioscience. Recent advances in genomics and proteomics have paved the way for an explosion of interest in protein structure and function. This book captures the current state of excitement in a way that all biosciences students will find appealing. Online Resource Centre: - Downloadable figures - A Web link library - Animated illustrations (pictures of complicated structures are much more effective if presented as animations; this will take the form of a computer-readable supplement to the book).