Database Annotation in Molecular Biology: Principles and Practice pdf

Arthur Mallay Lesk, est un chercheur en science des protéines, qui est professeur de biochimie et de biologie moléculaire à la Pennsylvania State University à University Park. Lesk a obtenu un baccalauréat, magna cum laude, de l'Université de Harvard en 1961. Il a obtenu son doctorat de l'Université de Princeton en 1966. Il a également obtenu une maîtrise de l'Université de Cambridge au Royaume-Uni en 1999. Lesk a apporté des contributions importantes à l'étude de l'évolution des protéines. Lui et Cyrus Chothia, travaillant au Medical Research Council (UK) Laboratory of Molecular Biology à Cambridge, Royaume-Uni, ont découvert la relation entre les modifications de la séquence des acides aminés et les modifications de la structure des protéines en analysant le mécanisme d'évolution des familles de protéines. Cette découverte a fourni la base quantitative de la méthode de prédiction de structure la plus réussie et la plus largement utilisée, connue sous le nom de modélisation par homologie.

Database Annotation in Molecular Biology: Principles and Practice pdf par Arthur Mallay Lesk

Two factors dominate current molecular biology: the amount of raw data is increasing very rapidly and successful applications in biomedical research require carefully curated and annotated databases. The quality of the experimental data -- especially nucleic acid sequences -- is satisfactory; however, annotations depend on features inferred from the data rather than measured directly, for instance the identification of genes in genome sequences. It is essential that these inferences are as accurate as possible and this requires human intervention.
With the recognition of the importance of accurate database annotation and the requirement for individuals with particular constellations of skills to carry it out, annotators are emerging as specialists within the profession of bioinformatics. This book compiles information about annotation -- its current status, what is required to improve it, what skills must be brought to bear on database curation and hence what is the proper training for annotators.
The book should be essential reading for all people working on biological databases, both biologists and computer scientists. It will also be of interest to all users of such databases, including molecular biologists, geneticists, protein chemists, clinicians and drug developers.