Introduction to Genomics pdf

Arthur Mallay Lesk, est un chercheur en science des protéines, qui est professeur de biochimie et de biologie moléculaire à la Pennsylvania State University à University Park. Lesk a obtenu un baccalauréat, magna cum laude, de l'Université de Harvard en 1961. Il a obtenu son doctorat de l'Université de Princeton en 1966. Il a également obtenu une maîtrise de l'Université de Cambridge au Royaume-Uni en 1999. Lesk a apporté des contributions importantes à l'étude de l'évolution des protéines. Lui et Cyrus Chothia, travaillant au Medical Research Council (UK) Laboratory of Molecular Biology à Cambridge, Royaume-Uni, ont découvert la relation entre les modifications de la séquence des acides aminés et les modifications de la structure des protéines en analysant le mécanisme d'évolution des familles de protéines. Cette découverte a fourni la base quantitative de la méthode de prédiction de structure la plus réussie et la plus largement utilisée, connue sous le nom de modélisation par homologie.

Introduction to Genomics pdf par Arthur Mallay Lesk

Our genome is the blueprint to our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism. But it is more than a static information store: our genome is a dynamic, tightly-regulated collection of genes, which switch on and off in many combinations to give the variety of cells from which our bodies are formed. But how do we identify the genes that make up our genome? How do we determine their function? And how do different genes form the regulatory networks that direct the process of life?
Introduction to Genomics is a fascinating insight into what can be revealed from the study of genomics: how organisms differ or match; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genomics means in terms of our future health and wellbeing.
Covering the lastest techniques that enable us to study the genome in ever-increasing detail, the book explores what the genome tells us about life at the level of the molecule, the cell, and the organism. Learning features throughout make this book the ideal teaching and learning tool: extensive end of chapter exercises and problems help the student to fully grasp the concepts being presented, while end of cahpter WebLems (web-based problems) and lab assignments give the student the opportunity to engage with the subject in a hands-on manner.