Introduction to Protein Architecture: The Structural Biology of Proteins pdf

Arthur Mallay Lesk, est un chercheur en science des protéines, qui est professeur de biochimie et de biologie moléculaire à la Pennsylvania State University à University Park. Lesk a obtenu un baccalauréat, magna cum laude, de l'Université de Harvard en 1961. Il a obtenu son doctorat de l'Université de Princeton en 1966. Il a également obtenu une maîtrise de l'Université de Cambridge au Royaume-Uni en 1999. Lesk a apporté des contributions importantes à l'étude de l'évolution des protéines. Lui et Cyrus Chothia, travaillant au Medical Research Council (UK) Laboratory of Molecular Biology à Cambridge, Royaume-Uni, ont découvert la relation entre les modifications de la séquence des acides aminés et les modifications de la structure des protéines en analysant le mécanisme d'évolution des familles de protéines. Cette découverte a fourni la base quantitative de la méthode de prédiction de structure la plus réussie et la plus largement utilisée, connue sous le nom de modélisation par homologie.

Introduction to Protein Architecture: The Structural Biology of Proteins pdf par Arthur Mallay Lesk

Written in a clear and engaging style, and profusely illustrated with superb computer graphics, Introduction to Protein Architecture is a textbook for second and third year undergraduate students and beginning post-graduate students, and will be of interest to all biological and medical scientists whose work touches on proteins.
The structures and functions of proteins unlock the secrets inherent in genomes, including the human genome. The emphasis of this book is on protein architecture, on proteins as three-dimensional patterns. A new field, bioinformatics, has grown up around gene and protein sequences and structures. It has captured the interest of many scientists for its intellectual challenges, its potential for useful applications, and promising scope for careers. This book introduces the use of the World Wide Web in bioinformatics.
Written by one of the leaders in this field, Introduction to Protein Architecture explains the general characteristics of proteins that underlie the very great variety of folding patterns observed in nature. For specialists in structural biology, it contains the core of what they need to know. For students and workers in related disciplines, undergraduates or beginning graduate students in biology, chemistry, medicine, bioinformatics, and related fields it contains what they will be able to apply to their own work. Topics treated include: Pattern and form in protein structure; The building blocks; The relationship between amino acid sequence and protein structure; Secondary, supersecondary and tertiary structure; Classifications and hierarchies of protein folding patterns; Protein evolution; How proteins change conformation (and why).