Introduction to Protein Science: Architecture, Function, and Genomics pdf

Артур Маллей Леск, исследователь белков, профессор биохимии и молекулярной биологии в Университете штата Пенсильвания в Университетском парке. Леск получил степень бакалавра с отличием в Гарвардском университете в 1961 году. Он получил докторскую степень в Принстонском университете в 1966 году. Он также получил степень магистра в Кембриджском университете в Соединенном Королевстве в 1999 году. Леск внес значительный вклад к изучению эволюции белков. Он и Сайрус Чотиа, работающие в Лаборатории молекулярной биологии Совета медицинских исследований (Великобритания) в Кембридже, Великобритания, обнаружили взаимосвязь между изменениями в аминокислотной последовательности и изменениями в структуре белка путем анализа механизма эволюции белковых семейств. открытие обеспечило количественную основу для наиболее успешного и широко используемого метода предсказания структуры, известного как моделирование гомологии.

Introduction to Protein Science: Architecture, Function, and Genomics pdf Артур Малли Леск

Proteins are essential to life, having a vital role in all living organisms. They are the ultimate micro machines: some are building blocks, joining with other substances to make the cells from which we are all formed. Some are catalysts, speeding up essential biochemical reactions to keep our cells alive. Yet others help cells to communicate, to move, and to build up the complex mix of tissues that make up our bodies. Introduction to Protein Science provides a broad ranging introduction to the contemporary study of proteins suitable for students on biosciences degrees internationally. Starting by describing the structure of proteins and how these structures can be studied, the book goes on to illustrate the wide range of functions that proteins have, showing how the shape of a protein is intimately linked to the function that it has. The book then describes how new experimental and computational techniques are helping us to predict a protein s structure and function, and how this is paving the way for us to design new proteins with specific characteristics, with exciting implications in areas such as drug design. Written by Arthur Lesk, the author of the highly successful Introduction to Bioinformatics, this book offers the same clear, student friendly approach to an equally important area of bioscience. Recent advances in genomics and proteomics have paved the way for an explosion of interest in protein structure and function. This book captures the current state of excitement in a way that all biosciences students will find appealing. Online Resource Centre: - Downloadable figures - A Web link library - Animated illustrations (pictures of complicated structures are much more effective if presented as animations; this will take the form of a computer-readable supplement to the book).