Introduction to Genomics

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Arthur Mallay Lesk, University Park'taki Pennsylvania Eyalet Üniversitesi'nde biyokimya ve moleküler biyoloji profesörü olan bir protein bilimi araştırmacısıdır. Lesk, 1961'de Harvard Üniversitesi'nden yüksek dereceli bir lisans derecesi aldı. Doktora derecesini 1966'da Princeton Üniversitesi'nden aldı. Ayrıca 1999'da Birleşik Krallık'taki Cambridge Üniversitesi'nden yüksek lisans derecesi aldı. Lesk önemli katkılarda bulundu. protein evrimi çalışmasına. O ve İngiltere, Cambridge'deki Tıbbi Araştırma Konseyi (Birleşik Krallık) Moleküler Biyoloji Laboratuvarı'nda çalışan Cyrus Chothia, protein ailelerindeki evrim mekanizmasını analiz ederek amino asit dizisindeki değişiklikler ile protein yapısındaki değişiklikler arasındaki ilişkiyi keşfettiler. keşif, homoloji modellemesi olarak bilinen en başarılı ve yaygın olarak kullanılan yapı tahmini yöntemi için nicel bir temel sağlamıştır.

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Introduction to Genomics kitap pdf oku ve indir Arthur Mallay Lesk

Our genome is the blueprint to our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism. But it is more than a static information store: our genome is a dynamic, tightly-regulated collection of genes, which switch on and off in many combinations to give the variety of cells from which our bodies are formed. But how do we identify the genes that make up our genome? How do we determine their function? And how do different genes form the regulatory networks that direct the process of life?
Introduction to Genomics is a fascinating insight into what can be revealed from the study of genomics: how organisms differ or match; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genomics means in terms of our future health and wellbeing.
Covering the lastest techniques that enable us to study the genome in ever-increasing detail, the book explores what the genome tells us about life at the level of the molecule, the cell, and the organism. Learning features throughout make this book the ideal teaching and learning tool: extensive end of chapter exercises and problems help the student to fully grasp the concepts being presented, while end of cahpter WebLems (web-based problems) and lab assignments give the student the opportunity to engage with the subject in a hands-on manner.

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