Introduction to Genomics pdf

亚瑟·马利·莱斯克 是一名蛋白质科学研究人员，他是位于大学公园的宾夕法尼亚州立大学的生物化学和分子生物学教授。 Lesk 于 1961 年以优异成绩获得哈佛大学学士学位。1966 年获得普林斯顿大学博士学位。他还于 1999 年获得英国剑桥大学硕士学位。Lesk 做出了重大贡献 用于蛋白质进化的研究。 他和在英国剑桥医学研究委员会（英国）分子生物学实验室工作的 Cyrus Chothia 通过分析蛋白质家族的进化机制，发现了氨基酸序列变化与蛋白质结构变化之间的关系。 发现为最成功和广泛使用的结构预测方法（称为同源建模）提供了定量基础。

Introduction to Genomics pdf 亚瑟·马利·莱斯克

Our genome is the blueprint to our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism. But it is more than a static information store: our genome is a dynamic, tightly-regulated collection of genes, which switch on and off in many combinations to give the variety of cells from which our bodies are formed. But how do we identify the genes that make up our genome? How do we determine their function? And how do different genes form the regulatory networks that direct the process of life?
Introduction to Genomics is a fascinating insight into what can be revealed from the study of genomics: how organisms differ or match; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genomics means in terms of our future health and wellbeing.
Covering the lastest techniques that enable us to study the genome in ever-increasing detail, the book explores what the genome tells us about life at the level of the molecule, the cell, and the organism. Learning features throughout make this book the ideal teaching and learning tool: extensive end of chapter exercises and problems help the student to fully grasp the concepts being presented, while end of cahpter WebLems (web-based problems) and lab assignments give the student the opportunity to engage with the subject in a hands-on manner.