Introduction to Protein Science: Architecture, Function, and Genomics

Introduction to Protein Science: Architecture, Function, and Genomics pdf

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709

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英语

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技术

页数:

334

部分:

生物信息学

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18018737 MB

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亚瑟·马利·莱斯克 是一名蛋白质科学研究人员,他是位于大学公园的宾夕法尼亚州立大学的生物化学和分子生物学教授。 Lesk 于 1961 年以优异成绩获得哈佛大学学士学位。1966 年获得普林斯顿大学博士学位。他还于 1999 年获得英国剑桥大学硕士学位。Lesk 做出了重大贡献 用于蛋白质进化的研究。 他和在英国剑桥医学研究委员会(英国)分子生物学实验室工作的 Cyrus Chothia 通过分析蛋白质家族的进化机制,发现了氨基酸序列变化与蛋白质结构变化之间的关系。 发现为最成功和广泛使用的结构预测方法(称为同源建模)提供了定量基础。

书的描述

Introduction to Protein Science: Architecture, Function, and Genomics pdf 亚瑟·马利·莱斯克

Proteins are essential to life, having a vital role in all living organisms. They are the ultimate micro machines: some are building blocks, joining with other substances to make the cells from which we are all formed. Some are catalysts, speeding up essential biochemical reactions to keep our cells alive. Yet others help cells to communicate, to move, and to build up the complex mix of tissues that make up our bodies. Introduction to Protein Science provides a broad ranging introduction to the contemporary study of proteins suitable for students on biosciences degrees internationally. Starting by describing the structure of proteins and how these structures can be studied, the book goes on to illustrate the wide range of functions that proteins have, showing how the shape of a protein is intimately linked to the function that it has. The book then describes how new experimental and computational techniques are helping us to predict a protein s structure and function, and how this is paving the way for us to design new proteins with specific characteristics, with exciting implications in areas such as drug design. Written by Arthur Lesk, the author of the highly successful Introduction to Bioinformatics, this book offers the same clear, student friendly approach to an equally important area of bioscience. Recent advances in genomics and proteomics have paved the way for an explosion of interest in protein structure and function. This book captures the current state of excitement in a way that all biosciences students will find appealing. Online Resource Centre: - Downloadable figures - A Web link library - Animated illustrations (pictures of complicated structures are much more effective if presented as animations; this will take the form of a computer-readable supplement to the book).

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