Pharmaceutical Biocatalysis: Drugs, Genetic Diseases, and Epigenetics pdf

Peter Grünwald 是荷兰阿姆斯特丹 CWI 机器学习小组的负责人。 他还是莱顿大学数学研究所统计学习的全职教授。 目前是计算学习协会主席，该组织运行 COLT，这是世界上机器学习理论的主要年度会议，他在 2015 年担任 COLT 的联合项目主席，并在 2010/2011 年主持了另一个顶级机器学习会议 UAI。 除了在 NIPS、COLT 和 UAI 等 ML 场所发表文章外，他还定期为统计期刊（例如 Annals of Statistics）撰稿。 他是《最小描述长度原则》一书的作者（麻省理工学院出版社，2007 年；请参阅此处了解最新 (2020 年)，更短的介绍），该书已成为 MDL 学习方法的标准参考。 2010 年，他与他人共同获得了 Van Dantzig 奖，这是荷兰统计和运筹学领域的最高奖项。 他获得了 NWO VIDI (2005)、VICI (2010) 和 TOP-1 (2016) 的资助。

Pharmaceutical Biocatalysis: Drugs, Genetic Diseases, and Epigenetics pdf 彼得·格伦瓦尔德

Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals, which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail, novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors, molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins, and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore, microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems, the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes, and the removal of pharmaceutical pollution from municipal sewage using laccase.